Origanum vulgare L. a review on genetic diversity, cultivation, biological activities and perspectives for molecular breeding
Keywords:
cultivation, essential oil, genetic diversity, molecular breeding, Origanum vulgare L., taxonomy, terpene synthase genesAbstract
Origanum vulgare L. or simply called oregano is a flowering plant of the Lamiaceae family, which has been known since ancient times due to its diverse properties and applications as a culinary spice but also as a herb with medicinal properties. It is widespread throughout the Mediterranean, Western and Southwestern Eurasia and in the Irano-Turanian regions. Being a popular medicinal plant with well-known application in traditional medicine due to its antibacterial, antifungal and anti-inflammatory properties among others, O. vulgare has been a subject of extensive research related to analysis of genetic diversity, possibility for cultivation as well as analysis of the composition and biological activities of its essential oil and plant extracts. Here we present a short review on this species with an accent on the recent progress in genetic diversity studies, applying modern DNA marker systems, possibilities for cultivation, composition and evaluation of the biological activities of the obtained essential oil and different plant extracts as well as the perspectives for molecular breeding of improved cultivars with desired agronomic traits, based on the current and emerging knowledge.
References
Alves-Pereira, I. M. S. & Fernandes-Ferreira, M. (1998). Essential oils and hydrocarbons from leaves and calli of Origanum vulgare ssp. virens. Phytochemistry, 48(5), 795-799.
Amar, M. & Wahab, M. A. E. (2013). Compartive genetic study among Origanum L. plants grown in Egypt. Journal of Biodiversity and Environmental Sciences, 3(12), 208-222.
Araniti, F., Landi, M., Lupini, A., Sunseri, F., Guidi, L. & Abenavoli, M. R. (2018). Origanum vulgare essential oils inhibit glutamate and aspartate metabolism altering the photorespiratory pathway in Arabidopsis thaliana seedlings. J. Plant Physiol., 231, 297-309.
Argyropoulos, E. I., Eleftherohorinos, I. & Vokou, D. (2008). In vitro evaluation of essential oils from Mediterranean aromatic plants of the Lamiaceae for weed control in tomato and cotton crops. Allelopathy Journal, 22(1), 69-78.
Aruoma, O. I. (1998). Free radicals, oxidative stress, and antioxidants in human health and disease. Journal of the American Oil Chemists Society, 75(2), 199-212.
Asensio, C. M., Grosso, N. R. & Juliani, H. R. (2015). Quality preservation of organic cottage cheese using oregano essential oils. Lwt-Food Science and Technology, 60(2), 664-671.
Asensio, C. M., Nepote, V. & Grosso, N. R. (2012). Sensory attribute preservation in extra virgin olive oil with addition of oregano essential oil as natural antioxidant. Journal of Food Science, 77(9), 294-301.
Azizi, A., Hadian, J., Gholami, M., Friedt, W. & Honermeier, B. (2012). Correlations between genetic, morphological, and chemical diversities in a germplasm collection of the medicinal plant Origanum vulgare L. Chemistry & Biodiversity, 9(12), 2784-2801.
Azizi, A., Wagner, C., Honermeier, B. & Friedt, W. (2009). Intraspecific diversity and relationship between subspecies of Origanum vulgare revealed by comparative AFLP and SAMPL marker analysis. Plant Systematics and Evolution, 281(1-4), 151-160.
Balusamy, S. R., Perumalsamy, H., Huq, M. A. & Balasubramanian, B. (2018). Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell lines. Biomed Pharmacother, 108, 1835-1844.
Baranauskiene, R., Venskutonis, P. R., Dambrauskiene, E. & Viskelis, P. (2013). Harvesting time influences the yield and oil composition of Origanum vulgare L. ssp vulgare and ssp hirtum. Industrial Crops and Products, 49, 43-51.
Barbosa, I. D., Medeiros, J. A. D., de Oliveira, K. A. R., Gomes-Neto, N. J., Tavares, J. F., Magnani, M. & de Souza, E. L. (2016). Efficacy of the combined application of oregano and rosemary essential oils for the control of Escherichia coli, Listeria monocytogenes and Salmonella enteritidis in leafy vegetables. Food Control, 59, 468-477.
Baricevic, D. (1997). Experiences with oregano (Origanum spp.) in Slovenia. In: Oregano. Promoting the conservation and use of underutilized and neglected crops. 14. Proceedings of the IPGRI International/Workshop on Oregano, Italy, 110-120.
Bedoya-Serna, C. M., Dacanal, G. C., Fernandes, A. M. & Pinho, S. C. (2018). Antifungal activity of nanoemulsions encapsulating oregano (Origanum vulgare) essential oil: in vitro study and application in Minas Padrao cheese. Braz J Microbiol, 49(4), 929-935.
Begnini, K. R., Nedel, F., Lund, R. G., Carvalho, P. H., Rodrigues, M. R., Beira, F. T. & Del-Pino, F. A. (2014). Composition and antiproliferative effect of essential oil of Origanum vulgare against tumor cell lines. J. Med. Food, 17(10), 1129-1133.
Ben-Ari, G. & Lavi, U. (2012). Marker-assisted selection in plant breeding. Plant Biotechnology and Agriculture: Prospects for the 21st Century, 163-184.
Bernath, J. (1997). Some scientific and practical aspects of production and utilisation of oregano in Central Europe. In: Oregano. Promoting the conservation and use of underutilized and neglected crops. 14. Proceedings of the IPGRI International Workshop on Oregano, Italy, 75-92.
Berrington, D. & Lall, N. (2012). Anticancer activity of certain herbs and spices on the Cervical Epithelial Carcinoma (HeLa) cell line. Evid Based Complement Alternat Med, 2012, 564927.
Brondani, L. P., Neto, T. A. d. S., Freitag, R. A. & Lund, R. G. (2018). Evaluation of anti-enzyme properties of Origanum vulgare essential oil against oral Candida albicans. Journal de Mycologie Médicale, 28(1), 94-100.
Burt, S. (2004). Essential oils: their antibacterial properties and potential applications in foods - a review. International Journal of Food Microbiology, 94(3), 223-253.
Canter, P. H., Thomas, H. & Ernst, E. (2005). Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology. Trends Biotechnol, 23(4), 180-185.
Cardoso, L. G., Santos, J. C. P., Camilloto, G. P., Miranda, A. L., Druzian, J. I. & Guimardes, A. G. (2017). Development of active films poly (butylene adipate co-terephthalate) - PBAT incorporated with oregano essential oil and application in fish fillet preservation. Industrial Crops and Products, 108, 388-397.
Collard, B. C. Y. & Mackill, D. J. (2008). Marker-assisted selection: an approach for precision plant breeding in the twenty-first century. Philosophical Transactions of the Royal Society B-Biological Sciences, 363(1491), 557-572.
Crocoll, C. (2011). Biosynthesis of the phenolic monoterpenes, thymol and carvacrol, by terpene synthases and cytochrome P450s in oregano and thyme. Dissertation, Max-Planck-Institut für chemische Ökologie, Jena, Germany.
Crocoll, C., Asbach, J., Novak, J., Gershenzon, J. & Degenhardt, J. (2010). Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis. Plant Mol. Biol., 73(6), 587-603.
D'Antuono, L. F., Galletti, G. C. & Bocchini, P. (2000). Variability of essential oil content and composition of Origanum vulgare L. populations from a North Mediterranean Area (Liguria Region, Northern Italy). Annals of Botany, 86(3), 471-478.
De Mastro, G., Fracchiolla, M., Verdini, L. & Montemurro, P. (2006). Oregano and its potential use as bioherbicide. Acta Horticulturae, 723, 335-345.
de Souza, G. T., de Carvalho, R. J., de Sousa, J. P., Tavares, J. F., Schaffner, D., de Souza, E. L. & Magnani, M. (2016). Effects of the essential oil from Origanum vulgare L. on survival of pathogenic bacteria and starter lactic acid bacteria in Semihard Cheese broth and slurry. J Food Prot, 79(2), 246-252.
de Sousa, L. L., de Andrade, S. C., Athayde, A. J., de Oliveira, C. E., de Sales, C. V., Madruga, M. S. & de Souza, E. L. (2013). Efficacy of Origanum vulgare L. and Rosmarinus officinalis L. essential oils in combination to control postharvest pathogenic Aspergilli and autochthonous mycoflora in Vitis labrusca L. (table grapes). Int J Food Microbiol, 165(3), 312-318.
Degenhardt, J., Kollner, T. G. & Gershenzon, J. (2009). Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants. Phytochemistry, 70(15-16), 1621-1637.
Ding, H. Y., Chou, T. H. & Liang, C. H. (2010). Antioxidant and antimelanogenic properties of rosmarinic acid methyl ester from Origanum vulgare. Food Chemistry, 123(2), 254-262.
Diniz-Silva, H. T., de Sousa, J. B., Guedes, J. S., Queiroga, R. C. R. E., Madruga, M. S., Tavares, J. F., de Souza, E. L. & Magnani, M. (2019). A synergistic mixture of Origanum vulgare L. and Rosmarinus officinalis L. essential oils to preserve overall quality and control Escherichia coli O157:H7 in fresh cheese during storage. LWT.
dos Santos, N. S., Aguiar, A. J. A., de Oliveira, C. E., de Sales, C. V., de Melo, E. S. S., da Silva, R. S., Stamford, T. C. & de Souza, E. L. (2012). Efficacy of the application of a coating composed of chitosan and Origanum vulgare L. essential oil to control Rhizopus stolonifer and Aspergillus niger in grapes (Vitis labrusca L.). Food Microbiol, 32(2), 345-353.
Du, W. X., Olsen, C. W., Avena-Bustillos, R. J., McHugh, T. H., Levin, C. E., Mandrell, R. & Friedman, M. (2009). Antibacterial effects of allspice, garlic, and oregano essential oils in tomato films determined by Overlay and Vapor-Phase methods. Journal of Food Science, 74(7), 390-397.
Dutra, T. V., Castro, J. C., Menezes, J. L., Ramos, T. R., do Prado, I. N., Machinski, M., Mikcha, J. M. G. & de Abreu, B. A. (2019). Bioactivity of oregano (Origanum vulgare) essential oil against Alicyclobacillus spp. Industrial Crops and Products, 129, 345-349.
Fernandes, R. P. P., Trindade, M. A., Lorenzo, J. M. & de Melo, M. P. (2018). Assessment of the stability of sheep sausages with the addition of different concentrations of Origanum vulgare extract during storage. Meat Science, 137, 244-257.
Fleming, T. (2000). PDR for herbal medicines (2nd ed.). Medical Economics, Montvale (US).
Fortunato, I. M., Avato, P. & Ruta, C. (2006). Glandular hairs and essential oils in micropropagated plants of Origanum vulgare L. In: Proceedings of the 1st International Symposium on the Labiatae: Advances in Production, Biotechnology and Utilisation, Italy, 295-298.
Foti, M. C. (2007). Antioxidant properties of phenols. Journal of Pharmacy and Pharmacology, 59(12), 1673-1685.
Franz, C. & Novak, J. (2002). Breeding of oregano. In: Oregano: The genera Origanum and Lippia, S. E. Kintzios. Taylor and Francis CRC Press, USA, 25,163-174.
Garcia-Beltran, J. M., Espinosa, C., Guardiola, F. A. & Esteban, M. A. (2018). In vitro effects of Origanum vulgare leaf extracts on gilthead seabream (Sparus aurata L.) leucocytes, cytotoxic, bactericidal and antioxidant activities. Fish & Shellfish Immunology, 79, 1-10.
Garcia-Beltran, J. M. & Esteban, M. A. (2016). Properties and applications of plants of Origanum sp. genus. SM Journal of Biology, 2(1), 1006.
Gaur, S., Kuhlenschmidt, T. B., Kuhlenschmidt, M. S. & Andrade, J. E. (2018). Effect of oregano essential oil and carvacrol on Cryptosporidium parvum infectivity in HCT-8 cells. Parasitology International, 67(2), 170-175.
Gayoso, L., Roxo, M., Cavero, R. Y., Calvo, M. I., Ansorena, D., Astiasarán, I. & Wink, M. (2018). Bioaccessibility and biological activity of Melissa officinalis, Lavandula latifolia and Origanum vulgare extracts: Influence of an in vitro gastrointestinal digestion. Journal of Functional Foods, 44, 146-154.
Giannenas, I., Bonos, E., Christaki, E. & Florou-Paneri, P. (2018). Oregano: A feed additive with functional properties. Therapeutic Foods, 8, 179-208.
Giannenas, I., Florou-Paneri, P., Papazahariadou, M., Christaki, E., Botsoglou, N. A. & Spais, A. B. (2003). Effect of dietary supplementation with oregano essential oil on performance of broilers after experimental infection with Eimeria tenella. Arch Tierernahr, 57(2), 99-106.
Gilling, D. H., Kitajima, M., Torrey, J. R. & Bright, K. R. (2014). Antiviral efficacy and mechanisms of action of oregano essential oil and its primary component carvacrol against murine norovirus. Journal of Applied Microbiology, 116(5), 1149-1163.
Govaris, A., Botsoglou, E., Sergelidis, D. & Chatzopoulou, P. S. (2011). Antibacterial activity of oregano and thyme essential oils against Listeria monocytogenes and Escherichia coli O157:H7 in feta cheese packaged under modified atmosphere. Lwt-Food Science and Technology, 44(4), 1240-1244.
Govindarajan, M., Rajeswary, M., Hoti, S. L. & Benelli, G. (2016). Larvicidal potential of carvacrol and terpinen-4-ol from the essential oil of Origanum vulgare (Lamiaceae) against Anopheles stephensi, Anopheles subpictus, Culex quinquefasciatus and Culex tritaeniorhynchus (Diptera: Culicidae). Research in Veterinary Science, 104, 77-82.
Grieve, M. (1994). A modern herbal. Tiger, London.
Gurdian, C., Chouljenko, A., Solval, K. M., Boeneke, C., King, J. M. & Sathivel, S. (2017). Application of edible films containing oregano (Origanum vulgare) essential oil on Queso Blanco Cheese prepared with flaxseed (Linum usitatissimum) oil. Journal of Food Science, 82(6), 1395-1401.
Habibi, P., de Sa, M. F., da Silva, A. L., Makhzoum, A., da Luz Costa, J., Borghetti, I. A. & Soccol, C. R. (2016). Efficient genetic transformation and regeneration system from hairy root of Origanum vulgare. Physiol Mol Biol Plants, 22(2), 271-277.
Han, X. & Parker, T. L. (2017). Anti-inflammatory, tissue remodeling, immunomodulatory, and anticancer activities of oregano (Origanum vulgare) essential oil in a human skin disease model. Biochim Open, 4, 73-77.
Helsen, K., Jacquemyn, H., Hermy, M., Vandepitte, K. & Honnay, O. (2013). Rapid buildup of genetic diversity in founder populations of the Gynodioecious plant species Origanum vulgare after semi-natural grassland restoration. PLoS One, 8(6).
Hoareau, L. & DaSilva, E. J. (1999). Medicinal plants: a re-emerging health aid. Electronic Journal of Biotechnology, 2, 56-70.
Hussain, A. I., Anwar, F., Rasheed, S., Nigam, P. S., Janneh, O. & Sarker, S. D. (2011). Composition, antioxidant and chemotherapeutic properties of the essential oils from two Origanum species growing in Pakistan. Revista Brasileira de Farmacognosia, 21, 943-952.
Ietswaart, J. H. (1980). A taxonomic revision of the genus Origanum (Labiatae). Leiden University Press, The Hague (NL).
Ince, A. G., Karaca, M. & Elmasulu, S. Y. (2014). New microsatellite and CAPS-microsatellite markers for clarifying taxonomic and phylogenetic relationships within Origanum L. Molecular Breeding, 34(2), 643-654.
Jan, S., Mir, J. I., Shafi, W., Faktoo, S. Z., Singh, D. B., Wijaya, L., Alyemeni, M. N. & Ahmad, P. (2018). Divergence in tissue-specific expression patterns of genes associated with the terpeniod biosynthesis in two oregano species Origanum vulgare L., and Origanum majorana. Industrial Crops and Products, 123, 546-555.
Jedrzejczyk, I. (2018). Study on genetic diversity between Origanum L. species based on genome size and ISSR markers. Industrial Crops and Products, 126, 201-207.
Katsiotis, A., Nikoloudakis, N., Linos, A., Drossou, A. & Constantinidis, T. (2009). Phylogenetic relationships in Origanum spp. based on rDNA sequences and intra-genetic variation of Greek O. vulgare subsp hirtum revealed by RAPD. Scientia Horticulturae, 121(1), 103-108.
Khan, M., Khan, S. T., Khan, N. A., Mahmood, A., Al-Kedhairy, A. A. & Alkhathlan, H. Z. (2018). The composition of the essential oil and aqueous distillate of Origanum vulgare L. growing in Saudi Arabia and evaluation of their antibacterial activity. Arabian Journal of Chemistry, 11(8), 1189-1200.
Khosravi, A. R., Shokri, H., Kermani, S., Dakhili, M., Madani, M. & Parsa, S. (2011). Antifungal properties of Artemisia sieberi and Origanum vulgare essential oils against Candida glabrata isolates obtained from patients with vulvovaginal candidiasis. Journal de Mycologie Médicale, 21(2), 93-99.
Kim, S. I., Yoon, J. S., Jung, J. W., Hong, K. B., Ahn, Y. J. & Kwon, H. W. (2010). Toxicity and repellency of origanum essential oil and its components against Tribolium castaneum (Coleoptera: Tenebrionidae) adults. Journal of Asia-Pacific Entomology, 13(4), 369-373.
Kintzios, S. E. (2012). Oregano. In: Handbook of herbs and spices. 2nd edition, K. V. Peter. Woodhead Publishing Limited, UK, 2, 417-436.
Kokkini, S., Vokou, D. & Karousou, R. (1991). Morphological and chemical variation of Origanum vulgare L. in Greece. Botanica. Chronica, 10, 337-346.
Kokkini, S., Karousou, R., Hanlidou, E. & Lanaras, T. (2004). Essential oil composition of Greek (Origanum vulgare ssp. hirtum) and Turkish (O. onites) Oregano: a Tool for Their Distinction. Journal of Essential Oil Research, 16(4), 334-338.
Lambert, R. J. W., Skandamis, P. N., Coote, P. J. & Nychas, G. J. E. (2001). A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. Journal of Applied Microbiology, 91(3), 453-462.
Lemhadri, A., Zeggwagh, N. A., Maghrani, M., Jouad, H. & Eddouks, M. (2004). Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. J Ethnopharmacol, 92(2-3), 251-256.
Leyva-Lopez, N., Gutierrez-Grijalva, E. P., Vazquez-Olivo, G. & Heredia, J. B. (2017). Essential oils of oregano: Biological activity beyond their antimicrobial properties. Molecules, 22(6), 989.
Liang, C.-H., Chou, T.-H. & Ding, H.-Y. (2010). Inhibition of melanogensis by a novel origanoside from Origanum vulgare. Journal of Dermatological Science, 57(3), 170-177.
Licciardello, F., Muratore, G., Suma, P., Russo, A. & Nerin, C. (2013). Effectiveness of a novel insect-repellent food packaging incorporating essential oils against the red flour beetle (Tribolium castaneum). Innovative Food Science & Emerging Technologies, 19, 173-180.
Licina, B. Z., Stefanovic, O. D., Vasic, S. M., Radojevic, I. D., Dekic, M. S. & Comic, L. R. (2013). Biological activities of the extracts from wild growing Origanum vulgare L. Food Control, 33(2), 498-504.
Llana-Ruiz-Cabello, M., Maisanaba, S., Puerto, M., Pichardo, S., Jos, A., Moyano, R. & Camean, A. M. (2017). A subchronic 90-day oral toxicity study of Origanum vulgare essential oil in rats. Food and Chemical Toxicology, 101, 36-47.
Lukas, B., Samuel, R. & Novak, J. (2010). Oregano or marjoram? The enzyme gamma-terpinene synthase affects chemotype formation in the genus Origanum. Israel Journal of Plant Sciences, 58(3-4), 211-220.
Lukas, B., Schmiderer, C. & Novak, J. (2015). Essential oil diversity of European Origanum vulgare L. (Lamiaceae). Phytochemistry, 119, 32-40.
Machado, M., Dinis, A. M., Salgueiro, L., Cavaleiro, C., Custodio, J. B. A. & Sousa, M. d. C. (2010). Anti-Giardia activity of phenolic-rich essential oils: effects of Thymbra capitata, Origanum virens, Thymus zygis subsp. sylvestris, and Lippia graveolens on trophozoites growth, viability, adherence, and ultrastructure. Parasitology Research, 106(5), 1205-1215.
Majid, R., Ahmad, D. & Zargar, M. (2012). Antioxidant screening of ethanolic and aqueous extracts of Organum vulgare L. in-vitro. African Journal of Biochemistry Research, 6(13), 165-171.
Makri, O. (2002). Cultivation of oregano. In: Oregano: The genera Origanum and Lippia, S. E. Kintzios. Taylor and Francis CRC Press, USA, 25,153-162.
Marques, J. D., Volcao, L. M., Funck, G. D., Kroning, I. S., da Silva, W. P., Fiorentini, A. M. & Ribeiro, G. A. (2015). Antimicrobial activity of essential oils of Origanum vulgare L. and Origanum majorana L. against Staphylococcus aureus isolated from poultry meat. Industrial Crops and Products, 77, 444-450.
Marrelli, M., Cristaldi, B., Menichini, F. & Conforti, F. (2015). Inhibitory effects of wild dietary plants on lipid peroxidation and on the proliferation of human cancer cells. Food Chem Toxicol, 86, 16-24.
Marzi, V. (1997). Agricultural practices for oregano. In: Oregano. Promoting the conservation and use of underutilized and neglected crops. 14. Proceedings of the IPGRI International Workshop on Oregano, Italy, 61-68.
Matsubara, S., Ino, M., Murakami, K., Kamada, M. & Ishihara, I. (1996). Callus formation and plant regeneration of herbs in Perilla family (Labiatae). Scientific Reports of the Faculty of Agriculture - Okayama University (Japan), 23-30.
Mazzarrino, G., Paparella, A., Chaves-Lopez, C., Faberi, A., Sergi, M., Sigismondi, C., Compagnone, D. & Serio, A. (2015). Salmonella enterica and Listeria monocytogenes inactivation dynamics after treatment with selected essential oils. Food Control, 50, 794-803.
Meneses, R., Ocazionez, R. E., Martinez, J. R. & Stashenko, E. E. (2009). Inhibitory effect of essential oils obtained from plants grown in Colombia on Yellow fever virus replication in vitro. Annals of Clinical Microbiology and Antimicrobials, 8, 8.
Meyers, M. (2005). Oregano and marjoram: An Herb Society of America Guide to the Genus Origanum. The Herb Society of America. https://www.herbsociety.org/
Mfarrej, M. F. B. & Rara, F. M. (2019). Competitive, sustainable natural pesticides. Acta Ecologica Sinica, 39(2), 145-151.
Misharina, T. A., Burlakova, E. B., Fatkullina, L. D., Alinkina, E. S., Vorob'eva, A. K., Medvedeva, I. B., Erokhin, V. N., Semenov, V. A., Nagler, L. G. & Kozachenko, A. I. (2013). Effect of oregano essential oil on the engraftment and development of Lewis carcinoma in F1 DBA C57 black hybrid mice. Prikl Biokhim Mikrobiol, 49(4), 423-428.
Morshedloo, M. R., Craker, L. E., Salami, A., Nazeri, V., Sang, H. & Maggi, F. (2017). Effect of prolonged water stress on essential oil content, compositions and gene expression patterns of mono- and sesquiterpene synthesis in two oregano (Origanum vulgare L.) subspecies. Plant Physiol Biochem, 111, 119-128.
Nasr, M., Sendi, J. J., Moharramipour, S. & Zibaee, A. (2017). Evaluation of Origanum vulgare L. essential oil as a source of toxicant and an inhibitor of physiological parameters in diamondback moth, Plutella xylustella L. (Lepidoptera: Pyralidae). Journal of the Saudi Society of Agricultural Sciences, 16(2), 184-190.
Nimse, S. B. & Pal, D. (2015). Free radicals, natural antioxidants, and their reaction mechanisms. Rsc Advances, 5(35), 27986-28006.
Nosal, P., Kowalska, D., Bielanski, P., Kowal, J. & Kornas, S. (2014). Herbal formulations as feed additives in the course of rabbit subclinical coccidiosis. Ann. Parasitol., 60(1), 65-69.
Novak, J., Lukas, B., Bolzer, K., Grausgruber-Groger, S. & Degenhardt, J. (2008). Identification and characterization of simple sequence repeat markers from a glandular Origanum vulgare expressed sequence tag. Molecular Ecology Resources, 8(3), 599-601.
Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., Chiba, S., Atwood, C. S., Petersen, R. B. & Smith, M. A. (2001). Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology and Experimental Neurology, 60(8), 759-767.
Nybom, H. & Weising, K. (2007). DNA profiling of plants. In: Medicinal plants biotechnology, from basic to industrial applications, O. Kayser & W. J. Quax. Wiley-VCH, Weinheim, 73-95.
Ocana-Fuentes, A., Arranz-Gutierrez, E., Senorans, F. J. & Reglero, G. (2010). Supercritical fluid extraction of oregano (Origanum vulgare) essentials oils: anti-inflammatory properties based on cytokine response on THP-1 macrophages. Food Chem. Toxicol., 48(6), 1568-1575.
Paparella, A., Mazzarrino, G., Chaves-Lopez, C., Rossi, C., Sacchetti, G., Guerrieri, O. & Serio, A. (2016). Chitosan boosts the antimicrobial activity of Origanum vulgare essential oil in modified atmosphere packaged pork. Food Microbiol., 59, 23-31.
Paraskevakis, N. (2015). Effects of dietary dried Greek oregano (Origanum vulgare ssp hirtum) supplementation on blood and milk enzymatic antioxidant indices, on milk total antioxidant capacity and on productivity in goats. Animal Feed Science and Technology, 209, 90-97.
Pesavento, G., Calonico, C., Bilia, A. R., Barnabei, M., Calesini, F., Addona, R., Mencarelli, L., Carmagnini, L., Di Martino, M. C. & Lo Nostro, A. (2015). Antibacterial activity of Oregano, Rosmarinus and Thymus essential oils against Staphylococcus aureus and Listeria monocytogenes in beef meatballs. Food Control, 54, 188-199.
Petrou, S., Tsiraki, M., Giatrakou, V. & Savvaidis, I. N. (2012). Chitosan dipping or oregano oil treatments, singly or combined on modified atmosphere packaged chicken breast meat. Int. J. Food Microbiol., 156(3), 264-271.
Raut, J. S. & Karuppayil, S. M. (2014). A status review on the medicinal properties of essential oils. Industrial Crops and Products, 62, 250-264.
Raybaudi-Massilia, R. M., Mosqueda-Melgar, J., Soliva-Fortuny, R. & Martin-Belloso, O. (2009). Control of pathogenic and spoilage microorganisms in fresh-cut fruits and fruit juices by traditional and alternative natural antimicrobials. Comprehensive Reviews in Food Science and Food Safety, 8(3), 157-180.
Rojas-Grau, M. A., Raybaudi-Massilia, R. M., Soliva-Fortuny, R. C., Avena-Bustillos, R. J., McHugh, T. H. & Martin-Belloso, O. (2007). Apple puree-alginate edible coating as carrier of antimicrobial agents to prolong shelf-life of fresh-cut apples. Postharvest Biology and Technology, 45(2), 254-264.
Sallaud, C., Rontein, D., Onillon, S., Jabes, F., Duffe, P., Giacalone, C., Thoraval, S., Escoffier, C., Herbette, G., Leonhardt, N., Causse, M. & Tissier, A. (2009). A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites. Plant Cell, 21(1), 301-317.
Sanchez, G. & Aznar, R. (2015). Evaluation of natural compounds of plant origin for inactivation of enteric viruses. Food and Environmental Virology, 7(2), 183-187.
Sankar, R., Karthik, A., Prabu, A., Karthik, S., Shivashangari, K. S. & Ravikumar, V. (2013). Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anticancer activity. Colloids Surf B Biointerfaces, 108, 80-84.
Santoro, G. F., Cardoso, M. d. G., Guimaraes, L. G., Salgado, A. P., Menna-Barreto, R. F. & Soares, M. J. (2007). Effect of oregano (Origanum vulgare L.) and thyme (Thymus vulgaris L.) essential oils on Trypanosoma cruzi (Protozoa: Kinetoplastida) growth and ultrastructure. Parasitology Research, 100(4), 783-790.
Sarikurkcu, C., Zengin, G., Oskay, M., Uysal, S., Ceylan, R. & Aktumsek, A. (2015). Composition, antioxidant, antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies (subsp. vulgare and subsp. hirtum) essential oils. Industrial Crops and Products, 70, 178-184.
Sarrou, E., Tsivelika, N., Chatzopoulou, P., Tsakalidis, G., Menexes, G. & Mavromatis, A. (2017). Conventional breeding of Greek oregano (Origanum vulgare ssp. hirtum) and development of improved cultivars for yield potential and essential oil quality. Euphytica, 213(5).
Shan, B., Cai, Y. Z., Sun, M. & Corke, H. (2005). Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. Journal of Agricultural and Food Chemistry, 53(20), 7749-7759.
Shange, N., Makasi, T., Gouws, P. & Hoffman, L. C. (2019). Preservation of previously frozen black wildebeest meat (Connochaetes gnou) using oregano (Oreganum vulgare) essential oil. Meat Sci, 148, 88-95.
Skoufos, I., Tsinas, A., Giannenas, I., Voidarou, C., Tzora, A. & Skoufos, J. (2011). Effects of an oregano based dietary supplement on performance of broiler chickens experimentally infected with Eimeria Acervulina and Eimeria Maxima. Poultry Science, 48(3), 194-200.
Skoula, M. & Harborne, J. B. (2002). The taxonomy and chemistry of origanum. In: Oregano: The genera Origanum and Lippia, S. E. Kintzios. Taylor and Francis CRC Press, USA, 25, 67–108.
Svoboda, K. P., Finch, R. P., Cariou, E. & Deans, S. G. (1995). Production of volatile oils in tissue culture of Origanum vulgare and Tanacetum vulgare. In: Proceedings of the International Symposium on Medicinal and Aromatic Plants, Japan, 147-152.
Teixeira, B., Marques, A., Ramos, C., Serrano, C., Matos, O., Neng, N. R., Nogueira, J. M. F., Saraiva, J. A. & Nunes, M. L. (2013). Chemical composition and bioactivity of different oregano (Origanum vulgare) extracts and essential oil. Journal of the Science of Food and Agriculture, 93(11), 2707-2714.
Thanos, C. A., Kadis, C. C. & Skarou, F. (1995). Ecophysiology of germination in the aromatic plants thyme, savory and oregano (Labiatae). Seed Science Research, 5(3), 161-170.
Tholl, D. (2006). Terpene synthases and the regulation, diversity and biological roles of terpene metabolism. Curr Opin Plant Biol, 9(3), 297-304.
Thomidis, T. & Filotheou, A. (2016). Evaluation of five essential oils as bio-fungicides on the control of Pilidiella granati rot in pomegranate. Crop Protection, 89, 66-71.
Tibaldi, G., Fontana, E. & Nicola, S. (2011). Growing conditions and postharvest management can affect the essential oil of Origanum vulgare L. ssp hirtum (Link) Ietswaart. Industrial Crops and Products, 34(3), 1516-1522.
Turner, G., Gershenzon, J., Nielson, E. E., Froehlich, J. E. & Croteau, R. (1999). Limonene synthase, the enzyme responsible for monoterpene biosynthesis in peppermint, is localized to leucoplasts of oil gland secretory cells. Plant Physiol, 120(3), 879-886.
Van Looy, K., Jacquemyn, H., Breyne, P. & Honnay, O. (2009). Effects of flood events on the genetic structure of riparian populations of the grassland plant Origanum vulgare. Biological Conservation, 142, 870-878.
Vattekkatte, A., Garms, S., Brandt, W. & Boland, W. (2018). Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors. Org Biomol Chem, 16(3), 348-362.
Vujicic, M., Nikolic, I., Kontogianni, V. G., Saksida, T., Charisiadis, P., Orescanin-Dusic, Z., Blagojevic, D., Stosic-Grujicic, S., Tzakos, A. G. & Stojanovic, I. (2015). Methanolic extract of Origanum vulgare ameliorates type 1 diabetes through antioxidant, anti-inflammatory and anti-apoptotic activity. Br J Nutr, 113(5), 770-782.
Wiseman, H. & Halliwell, B. (1996). Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer. Biochemical Journal, 313, 17-29.
Zagorcheva, T., Rusanov, K., Stanev, S. & Atanassov, I. (2016). A simple procedure for comparative GC-MS analysis of lavender (Lavandula angustifolia Mill.) flower volatile composition. Journal of Pharmacy and Biological Sciences, 11(4), 9-14.
Zhang, X. L., Guo, Y. S., Wang, C. H., Li, G. Q., Xu, J. J., Chung, H. Y., Ye, W. C., Li, Y. L. & Wang, G. C. (2014). Phenolic compounds from Origanum vulgare and their antioxidant and antiviral activities. Food Chemistry, 152, 300-306.
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