Phenotypic and genetic characteristics of fecundity in sheep. A review
Keywords:
fecundity in sheep, gene expression, marker assisted selection, molecular marker applicationsAbstract
The phenotypic characteristics of animals are result of the complex interaction of a number of genetic and non-genetic factors, which usually act simultaneously and it is difficult to determine the degree of influence of each of them. Early identification of the genetic traits of individuals enables more efficient management of selection. Fertility determins the cost-effectiveness of sheep farming, regardless of productive direction. The individual fertility of the animals is determined by the number of lambs born per sheep. This trait is characterized by a low inheritance rate, hence conventional breeding methods shows slow progress. The introduction of new molecular-based technologies to improve productivity contributes to a greater and faster effect on the realization of animal genetic resources. The assessment of the breeding value of animals at the earliest possible age makes it possible to maximize the effect of the selection and to increase the use of animals with the highest genetic potential. The molecular markers and the application of RFLP-PCR method allow the determination of allelic variants of genes related to the quantity and quality of animal productivity. By identifying the different polymorphic variations and their phenotypic manifestation, a database can be accumulated to manage the genetic progression of economically important traits. Many mutations have been found in sheep that affect fertility and ovulation rates to varying degrees. Large number of mutations which affects ovulation have been found in genes expressing different proteins, such as the BMPR1B or FecB (Booroola gene or the bone morphogenetic protein receptor type 1B), GDF9 or FecG (the growth differentiation factor 9b) and BMP15 or FecX (a bone morphogenetic protein 15).
References
Abdoli, R., Zamani, P., Mirhoseini, S. Z., Ghavi Hossein-Zadeh, N. & Nadri, S. (2016). A review on prolificacy genes in sheep. Reproduction in Domestic Animals. 51, 631–637.
Barakat, I. A.H., Salem, L. M., Daoud, N. M., Khalil, W. K. B. & Mahrous, K. F. (2017). Genetic polymorphism of candidate genes for fecundity traits in Egyptiansheep breeds. Biomedical Research; 28 (2), 851-857.
Boikovski, S., Stancheva, N., Stefanova, G. & Dimitrov, D. (2003). Influence of some factors on biological prolificacy in sheep from newly created milk sheep breed. Bulgarian Journal of Agricultural Science, 9 (3), 391-397.
Borzan, M. M., Cîmpean, A., Pusta, D. & Pașca, I. (2015). Evaluation of some reproductive parameters of Tsurcana sheep crossed with Blanc du Massif Central rams. Bulletin UASVM Veterinary Medicine, 72(2), 420-423.
Chu, M. X., Cheng, R. H., Fang, L. & Ye, S. C. (2005). Study on bone morphogenetic protein as a candidate gene for prolificacy of Small Tailed Han sheep and Hu sheep. Journal Anhu Agric. Univ., 32, 278-282.
Davis, G. H., McEwan, J. C., Fennessy, P. F., Dodds, K. G &Farquhar, P.A. (1991). Evidence for the presence of a major gene influencing ovulation rate on the X chromosome of sheep. Biol Reprod, 44, 620-624.
Davis, G. H., Dodds, K. G., McEwan, J. C. & Fennessy, P.F. (1993). Live weight, fleece weight and prolificacy of Romney ewes carrying the Inverdale prolificacy gene (FecXI) located on the X-chromosome. Livest Prod Sci, 34, 83-91.
Dimitrov, l. (1978). Characteristics of breeding traits of the Ilede-France breed bred in Bulgaria I. Fertility of maternal sheep, weight development and carnival characteristics of lambs. Animal Science, 4, 58-67. (BG)
Dimov, D. (2000). Influence of some non-genetic factors on the variation of fertility in Vakli Marishki sheep. Animal Science, 4, 45-49. (Bg).
Djorbineva, M. (1984). Variability of breeding traits in local Stara Zagora sheep and opportunities for their improvement. Thesis, Sofia (Bg).
Djorbineva, M., Kalaidzhiev, G. & Dimitrov, I. (2011). Current and prospects for local Stara Zagora sheep. Agrarian Sciences, 6, 47-51. (Bg).
Fabre, S., Pierre, A., Mulsant, P., Bodin, L., Pasquale, E. Di., Persani, L., Monget, P. & Monniaux, D. (2006). Regulation of ovulation rate in mammals: contribution of sheep genetic models. Reproductive Biology and Endocrinology, 4, 20-32.
Fadare, А. (2015). Reproductive traits among Black, White and Brown West African Dwarf sheep. Livestock Research for Rural Development, 27(2), from http://www.lrrd.org/lrrd27/2/fada27024.html
Fahmy, M. H. (1986). Preliminary results on fertility, prolificacy, lamb production, and carcass traits of Romanov Sheep in Canada. 3rd World Congress on Genetics Applied to Livestock Production, 60. http://digitalcommons.unl.edu/wcgalp/60
Gemmell, N. J. & Slate, J. (2006). Heterozygote advantage for fecundity. PLoS ONE 1, e125.
Ghaderi, A., Beigi Nasiri, M. T., Mirzadeh, K. H., Fayazi, J. & Sadr, A. S. (2010). Identification of the GDF9 mutation in two sheep breeds by using polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) technique. African Journal of Biotechnology, 9(47),8020-8022.
Ghaffari, M., Nejati-Javaremi, A. & Rahimi, G., (2009). Detection of polymorphism in BMPR-IB gene associated with twining in Shal Sheep using PCR-RFLP Method. International Journal of Agriculture & Biology, 11, 97–99.
Hackett, A. J. & Wolynetz, M. S. (1985). Reproductive performance of Finnish Landrace and Suffolk sheep maintained indoors year-round. J. Anim. Sci., 60(2), 334-341
Hanrahan, J. P., Gregan, S. M., Mulsant, P., Mullen, M., Davis, G. H., Powell, R. & Galloway, S. (2004). Mutations in the genes for oocyte derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries). Biol Reprod., 70, 900-909.
Hansen, C., J. & Shrestha, N. B. (1997). Heritability and repeatability estimates for of ewe productivity traits of three breeds under 8-month breeding cycles and artificial rearing of lambs. Small Ruminant Research, 24, 185-194.
Hinkovski, Ts. (1972). Study on the non-genetic and genetic determination of fertility in the Askani breed of sheep in Bulgaria. I. Impact of individual sources of specific effect. Animal Science, 2, 15-21. (BG)
Hinkovski, Ts., Raycheva, E. & Metodiev, N. (2008). Evaluation of the productivity of sheep from the synthetic population of Bulgarian dairy. Animal Science, 3, 35-42. (BG), http://www.lrrd.org/lrrd27/2/fada27024.html
Ivanova, I., Dimova, N., Peeva, J., Djorbineva, M. & Mihailova, M. (2010). Relationship between some exterior dimensions and the assessment of body condition in sheep from the Synthetic population of Bulgarian dairy. Animal Science, 4, 14-19. (BG)
Knight, P.G. & Glister, C. (2006). TGF-ß super family members and ovarian follicle development. Reproduction, 132, 191-206.
Kominakis, A., Papavasiliou, D. & Rogdakis, E. (2009). Relationships among udder characteristics, milk yield, non-yield traits in Frizarta dairy sheep. Small Ruminant Research, 84, 82-88.
Kridli, R. T., Abdullah, A. Y. & Husein, M. Q. (2009). The effect of breed type and lactation status on reproductive performance in Awassi ewes. South African Journal of Animal Science, 39(1), 15-18.
Kumar, D., Joshi, A., Naqvi, S. M. K., Kumar, S., Mishra, A. K., Maurya, V. P. & Singh, V. K. (2007). Sperm motion characteristics of Garole × Malpura sheep evolved in a semi-arid tropical environment through introgression of FecB gene. Animal Reproduction Science, 100, 51–60.
Letterio, J. J. & Roberts, A. B. (1998). Regulation of immune responses by TGFbeta. Annu. Rev. Immunol., 16, 137–161.
Mahdavi, M., Nanekarani, S. & Hosseini, S. D. (2014). Mutation in BMPR-1B gene is associated with litter size in Iranian Kalehkoohi sheep. Animal Reproduction Science, 147, 93–98.
Martínez, J. A. R., Piña, R. G., Caratachea, A. J., Patiño, A. B., Espinoza, Villavicencio, J. L. & Razo, G. S. (2017). Estrus, fertility and prolificacy in Wool Sheep treated with Melengestrol Acetate on the reproductive and non-reproductive. Period. Transylvanian Review, XXV, (22), 5689-5695. https://www.researchgate.net/publication/322601293_Estrus_Fertility_and_Prolificacy_in_Wool_Sheep_Treated_With_Melengestrol_Acetate_on_the_Reproductive_and_Non-Reproductive_Period
Martinez-Royo, A., Jurado, J. J., Smulders, J. P., Martí, J. I., Alabart, J. L., Roche, A., Fantova, E., Bodin, L., Mulsant, P., Serrano, M., Folch, J. & Calvo, J. H. (2008). A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in Rasa Aragonesa sheep. Anim Genet., 39(3),294-7.
Massague, J. (1998). TGF-beta signal transduction. Annu. Rev. Biochem., 67, 753–791.
Metodiev, N., Raicheva, E. & Ralchev, I. (2010). Influence of the salt – free – salt diet and the ram effect on main reproductive traits of ewes from synthetic population Bulgarian milk. Bulg. J. Agric. Science, 16(6), 788-793.
Montgomery, G. W., Crawford, A. M., Penty, J. M., Dodds, K. G., Ede, A. J., Henry, H. M., Pierson, C. A., Lord, E. A., Galloway, S. M., Schmack, A. E. & Sise, J. A.
(1993). The ovine Booroola fecundity gene (FecB) is linked to markers from a region of human chromosome 4q. Nature Genetics, 4(4), ,410414.
Montgomery, G. W., Lord, E. A., Penty, J. M., Dodds, K. G., Broad, T. E., Cambridge, L., Sunden, S. L., Stone, R. T. & Crawford, A. M. (1994). The Booroola fecundity (FecB) gene maps to sheep chromosome 6. Genomics, 22(1), 148-153.
Moradband, F., Rahimiq, G. & Gholizadeh, M. (2011). Association of polymorphisms in fecundity genes of GDF9, BMP15 and BMP15-1B with litter size in Iranian Baluchi sheep. AsianAust. J. Anim. Sci., 24(9), 1179-1183.
Morris, C. A. (1990). Theoretical and realised responses to selection for reproductive rate. In: Proc. 4th World Congress on Genetics Applied to Livestock Production, Edinburgh, XVI, 309-318.
Mulsant, P., Lecerf, F., Fabre, S., Schibler, L., Monget, P., Lanneluc, I., Pisselet, C., Riquet, J., Monniaux, D., Callebaut, I., Cribiu, E., Thimonier, J., Teyssier, J., Bodin, L., Cognie, Y., Chitour, N. & Elsen, J. M. (2001). Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation in Booroola ewes. Proc. Natl. Acad. Sci. USA, 98, 5104-5109.
Piper, L. R. & Bindon, B. M. (1982). The Booroola Merino and the performance of medium non-Peppin crosses at Armidale. In: Piper, L.R., B.M. Bindon and R.D. Netherv (eds.), The Booroola Merino. Commonwealth Scientific and Industrial Research Organisation, Melbourne, 9.
Piper, L. R. & Bindon, B. M. (1996). The Booroola Merino. In: Fahmy, M.H. (ed.), Prolific sheep. CAB Int., Willingford, UK, 152–160.
Piper, L. R., Bindon, B. M. & Davis, G. H. (1985). The single gene inheritance of the high litter size of the Booroola Merino. In: Land, R.B. and D.W. Robinson (eds.), Genetics of reproduction in sheep,. London, 115–125.
Polley, S., Sachinandan, De., Brahma, B., Mukherjee, A., Vinesh, P. V., Batabyal, S., Arora, J. S., Pan, S., Samanta, A. K., Datta, T. K.& Goswami, S. L. (2010). Polymorphism of BMPR1B, BMP15 and GDF9 fecundity genes in prolific Garole sheep. Tropical Animal Health and Product, 42, 985–993.
Rosa, H. J. D., Ventura, P. F. M., Sousa, J. T., Moreira, D., Borba, A. E. S.& Rego, O. A. (2007). Productive and reproductive performance of Romney Marsh and Merino Branco sheep in the Azores under different feeding regimens. Small Ruminant Research, 67, 296–301.
Souza, C. J., MacDougall, C., Campbell, B. K., McNeilly, A. S. & Baird, D. T. (2001). The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1B (BMPR1B) gene. J. Endocrinol, 169, R1-R6.
Stancheva, N. (2003). Phenotype and genotype parameters of breeding traits in the newly created high-yielding sheep population in the country. Thesis, Sofia (Bg).
Su, Y. Q., Wu, X. O.ُ, Brien, M. J., Pendola, F. L., Denegre, J. N., Matzuk, M. M. & Eppig, J. J. (2004). Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte-cumulus cell complex in mice: genetic evidence for an oocyte- granulose cell regulatory loop. Dev. Biol., 276, 64-73.
Thomas, D., Berger, Y. & McKusick, B. (1999). East Friesian Germplasm: Effects on milk production, lamb growth and lamb survival. Proceedings of the American Society of Animal Science.
Thomas, D., Berger, Y., McKusick, B. & Gottfredson, R. (2000). Comparison of East Friesian – Crossbred and Lacaune – Crossbred ewe lambs from dairy sheep production. http://babcock.wisc.edu/sites/default/files/sheepgoat/sg_Comparison.pdf
Thomas, D., Berger, Y., Gottfredson, R. &Taylor, T. (2010). Comparison of East Friesian and Lacaune breeds for dairy sheep production in North America. http://www.ansci.wisc.edu/extension-new%20copy/sheep/Publications_and_Proceedings/symposium_04/pdf%20of%20Dairy%20Sheep%20Proceedings/Thomas%20Lacaune%20vs%20EF%2010GLDSS%2010-10-04%20Proc%20Ready.pdf
Wilson, T., Wu, X. Y., Juengel, J. L., Ross, I. K., Lumsden, J. M., Lord, E. A., Dodds, K. G., Walling, G. A., McEwan, J. C., O’Connell, A. R., McNatty, K. P. & Montgomery, G. W. (2001). Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells. Biol. Reprod., 64, 1225-1235.
Yousif, M., Al-Barzinji, S., Galawezh, U. & Othman, (2013). Genetic polymorphism in FecB gene in Iraqi sheep breeds using RFLP-PCR technique. Journal of Agriculture and Veterinary Science, 2(4), 46-48.
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