Field trials to establish the clininical equivalence of two 34% injectable solutions of nitroxinil in sheep, cattle and buffalo naturally infected with Fasciola hepatica and certain gastrointestinal nematodes

Abstract

The clinical equivalence in the field of two 34% injectable solutions of nitroxynil - Nitroxinil 34%
solution for injection - ”Investigation product” and Trodax 34% inj. sol. - ”Control product” in sheep,
cattle and buffaloes naturally infected with Fasciola hepatica and some gastrointestinal nematodes.
In each experiment three groups were formed – two experimental and one control. The experiments
were performed to compare and possibly confirm the clinical equivalence between the preparation
Nitroxinil 34% inj. sol. and the original Trodax product 34%. A total of 126 sheep of the Local
Improved breed were used, with a body weight of 40–50 kg, mostly female and of different ages. In
the experiments with cattle, 60 cattle from the cross X Local Chernoshareno and 30 buffaloes of the
breed ”Murrah”, of female sex with different live weight, were used. The test and control product
was administered at a dose of 10 mg/kg bw. or 1 ml for 34 kg m.p. Sheep, cattle and buffaloes were
injected once subcutaneously. In terms of its effectiveness, Nitroxinil 34% solution for injection does
not differ from the original product Trodax (P > 0.05), which leads to the conclusion that the two
preparations are equivalent in terms of their clinical efficacy.
The aim of the present study was to conduct a comparative clinical study of these two veterinary
medicinal products in terms of their efficacy.